This book is dedicated to my Mom, My Meama, My Aunt, and My older sister, who all have type 1 Osteogenesis Imperfecta. I also want to dedicate this book to the people who are struggling with OI and their families.

Page 1: Dedication page

Page 3: Introduction

Page 4: Symptoms

Page 5: Impact

Page 6: Data/research

Page 7: Diagram 1

Page 8: Diagram 2

Page 9: Graph

Page 10: Chart

page 11: Map

Page 12: Timeline

Page 13: Spine x-ray

Page 14: Arm x-ray

Page 15: Blue scarla image

Page 15: Double-jointed image

Page 16: Glossary

Inroduction

Brittle bones, fractures, and pain. These are just a few of the symptoms of Osteogenesis Imperfecta. Osteogenesis Imperfecta is a hereditary bone disease that significantly affects patients and their families; Doctors continue to treat and research it to give OI patients the best quality of life possible with their disease.

Symptoms

Osteogenesis Imperfecta is a rare genetic disorder that affects collagen formation. The predominant cause of Osteogenesis Imperfecta is genetic mutations in genes that encode type I collagen. Osteogenesis Imperfecta, also known as brittle bone disease or OI, is characterized by symptoms like altered bone formation, recurrent fractures, blue sclera, thin skin, bone deformities, low bone mass, early-onset hearing loss, curved spine, double-jointed, bowed legs, and reduced physical activity. Osteogenesis Imperfecta is a disease that significantly affects the quality of life for individuals with this disease.

Impact

Osteogenesis Imperfecta presents many struggles for the patient and their families, like inadequate recognition, poor care coordination, and incomplete information. (OI) can also have an impact on the caregivers and their community. Individuals with severe (OI), and especally the one's who require surgery, often present a more difficult management to ensure the patient with (OI) can live their life to the fullest possible.

 Treatment of (OI)

The current management or treatment approach to patients with OI is multidisciplinary, meaning the patient is given amteresarptive medications, physiotherapy, occupational therapy, and orthopedic surgery, which all provide relief but no cure, although doctors are continuing to research Osteogenesis Imperfecta's impacts and how to treat them, hoping to give the patients the best quality of life possible while managing their disease.

A comparison of a healthy human bone and a bone of someone with osteogenesis imperfecta.

Diagram/x-ray of individuals of different ages with different types of osteogenesis imperfecta.

A bar graph of a survey of the impacts of osteogenesis imperfecta on individuals with the disease.

Longitudinal growth curves for children with types III and type IV osteogenesis imperfecta.

Map of people with Osteogenesis imperfecta in the U.S from 1865-Dec 01to 2009-Dec 20.