Once upon a time.... there was Glucose, a very sad and lonely sugar molecule who wasn't happy with his life. 

Glucose had heard the mighty tales of "glycolysis" and wanted to fulfil his prophecy of becoming 2 pyruvate molecules.

GLYCOLISIS

I just want to become 2 pyruvate molecules!

Glucose had enough of this lonely life, he decided it was time. He was gonna set on the journey of glycolysis to fulfill his dream of becoming 2 pyruvate molecules! 

You know what, I'm gonna do it!

It was a long journey, glucose would have to travel through lots of different enzymes but he was determined. 

Finally glucose had made it to the cytosol, where his journey would take place as he would travel from one enzyme to the next. 

This is where it all begins....

With my help, I can give you a phosphate apart of ATP. 

ATP

Glucose made it to his first destination in the deep woods, and met enzyme Mrs. Hexokinase. 

Mrs. Hexokinase had the highly restricted ATP, an energy molecule glucose would need. 

+

Glucose was transformed into glucose-6-phosphate now with an inorganic phosphate attached to him, and Mrs. Hexokinase's ATP had turned into ADP. 

Thanks Mrs.Hexokinase!

Now glucose-6-phosphate had made it to enzyme Mr.Phosphoglucomutase's beauty salon, where he would receive an entire makeover. 

Oh my god, you look hideous.

Am I that ugly?

Mr. Phosphoglucomutase gave him a makeover, keeping all his parts but completely rearranging them turning him into his isomer fructose-6-phosphate.

Wow, I look amazing now!

After leaving Mr.Phosphoglucomutase's beauty salon, fructose-6-phosphate met Mrs.Phosphofructokinase, another enzyme who also had the highly restricted ATP.

With my help, I can give you a phosphate from this ATP.

ATP

Mrs.Phosphofructokinase used up her ATP giving an inorganic phosphate to fructose-6-phosphate, now making him fructose-1, 6-bisphosphate. Another ADP was produced.

Woohoo, I have 2  phosphates now!

However, on fructose-1, 6-bisphosphate's way to Mr.Adolse, something didn't feel right. 

I feel too heavy...

I can split you apart!

Enzyme Mr.Adolse forcefully split fructose-1, 6-bisphosphate into glyceraldehyde-3-phosphate (G3P) and dihydroxyacetone phosphate. (DHAP) But it still wasn't right, they needed to be the same 2 molecules.

9-1-1 we have an emergency!